Transactions on Additive Manufacturing Meets Medicine
Vol. 5 No. 1 (2023): Trans. AMMM
https://doi.org/10.18416/AMMM.2023.2309803

Medical Phantoms for Planning, Training, and Quality Assurance, ID 803

Development and validation of a 3D-printed artificial round window niche for use in release kinetics analysis of round window niche implants

Main Article Content

Martina Knabel (Department of Otorhinolaryngology, Hannover Medical School, Germany), Gerald Draeger (Department of Organic Chemistry, Leibniz University Hannover, Germany), Thomas Lenarz (Department of Otorhinolaryngology, Hannover Medical School, Germany), Verena Scheper (Department of Otorhinolaryngology, Hannover Medical School, Germany)

صندلی اداری سرور مجازی ایران Decentralized Exchange

Abstract

The regular way to determine the in vitro release rates of drugs from implantable drug delivery systems consists of the complete immersion of the implant into a medium. The medium surrounds the implant, and the diffusion of the drugs occurs across the whole implant surface directly into the medium. This method does not accurately model the release rates if the real diffusion only happens across only one part of the surface of the implant, through a membrane, and into a small volume of medium. It also does not address the anatomical shape of the studied structure. One example for this is the insertion of an implant at the round window niche (RWN) in the middle ear, which enables the diffusion of drugs through the round window membrane into the inner ear. To solve this problem, we designed, three dimensionally (3D) printed and validated an artificial RWN (aRWN) to analyze the diffusion of dexamethasone from round window niche implants (RNI) into artificial perilymph over time. The aRWN consists of a human sized scala tympani with an opening at the apex and round window, respectively. We adjusted the model to be able to position an artificial membrane over the round window area and place a round window niche implant (RNI) on top of it. The scala can be filled with artificial perilymph which can be sampled via the opening at the apex. The established aRWN incorporates small dimensions, small liquid volumes, geometry, and the diffusion through a membrane into the results of release kinetics experiments. It allows better understanding of the diffusion rates of drug delivery implants for the treatment of inner ear disorders through the RWN and RWM.


Acknowledgments
We thank Michaela Kreienmeyer and Tim Ehmann for the technical support.


Author’s statement
Authors state no conflict of interest.

Article Details

How to Cite

Knabel, M., Draeger, G., Lenarz, T., & Scheper, V. (2023). Development and validation of a 3D-printed artificial round window niche for use in release kinetics analysis of round window niche implants. Transactions on Additive Manufacturing Meets Medicine, 5(1), 803. https://doi.org/10.18416/AMMM.2023.2309803

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