Transactions on Additive Manufacturing Meets Medicine
Vol. 7 No. S1 (2025): Trans. AMMM Supplement
https://doi.org/10.18416/AMMM.2025.25062075

Critical-Sized Bone Defect Treatment, ID 2075

A clinician-friendly patient-specific scaffold design suite for treating bone defects

Main Article Content

Buddhi Herath ((1) Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia; (2) Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia), Kim MinJoo (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Giles Cheers (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Markus Laubach (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Yooseok Chae (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Sinduja Suresh ((1) Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia; (2) Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia), Christoph Thorwächter (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Paul Reidler (Department of Radiology, LMU University Hospital, LMU Munich, Germany), Stefan Leonhardt (Kumovis GmbH – a 3D Systems Company, Munich, Germany), Arnaud Bruyas (Kumovis GmbH – a 3D Systems Company, Munich, Germany), Susanne Mayer-Wagner (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Boris Holzapfel (Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, LMU Munich, Munich, Germany), Dietmar Hutmacher ((1) Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia; (2) Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia), Marie-Luise Wille ((1) Australian Research Council Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing, Queensland University of Technology, Brisbane, Australia; (2) Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, Australia)

Abstract

Scaffold-guided bone regeneration (SGBR) is a newly emerging bone defect treatment facilitated by the in-situ guidance of new bone tissue regeneration using a 3D-printed biodegradable structural support called a ‘scaffold’ that is customized to the patient's bone defect. SGBR has demonstrated efficacy in both pre-clinical and clinical studies in large bone defects. However, widespread clinical adoption remains limited due to the lack of a streamlined, cost-effective, and user-friendly design and manufacturing system. Preliminary work by the team [1], [2] resulted in a digital design workflow that can semi-automatically generate a scaffold design. It has been validated via two complex clinical cases, in the latter of which the scaffolds were successfully implanted. However, the current digital workflow, built within Rhinoceros 3D and Grasshopper, presents usability challenges for clinicians unfamiliar with computer aided design (CAD) platforms.



For clinical uptake not only is a user-friendly software solution with an intuitive and simple interface required, but also a scaffold manufacturing system that can be implemented in clinical settings. In close collaboration with surgeons and a 3D printing company, we are developing a standalone application for designing patient-specific scaffolds that can be readily 3D-printed using a compact cleanroom 3D printer. It features a modular interface which surgeons can intuitively combine to generate a scaffold design, without requiring extensive CAD expertise. Here, we present the first prototype of this software solution, which will be tested on 15 retrospective clinical cases.

Article Details

How to Cite

Herath, B., MinJoo, K., Cheers, G., Laubach, M., Chae, Y., Suresh, S., … Wille, M.-L. (2025). A clinician-friendly patient-specific scaffold design suite for treating bone defects. Transactions on Additive Manufacturing Meets Medicine, 7(S1), 2075. https://doi.org/10.18416/AMMM.2025.25062075

Most read articles by the same author(s)