Transactions on Additive Manufacturing Meets Medicine
Vol. 5 No. S1 (2023): Trans. AMMM Supplement

Scaffolds, Implants and Drug Delivery Systems, ID 800

Piezoelectric and bioactive composites: Functional materials for bone tissue engineering

Main Article Content

Christian Polley (University of Rostock), Thomas Distler (Institute of Biomaterials, Friedrich-Alexander-University Erlangen-Nuremberg), Rainer Detsch (Institute of Biomaterials, Friedrich-Alexander-University Erlangen-Nuremberg), Aldo R. Boccaccini (Institute of Biomaterials, Friedrich-Alexander-University Erlangen-Nuremberg), Hermann Seitz (Microfluidics, University of Rostock)


When deformed, piezoelectric biomaterials generate electricity, creating a microenvironment to electrically stimulate cells, which can restore essential functions in biological tissues. In previous studies, the beneficial effects of electrical stimulation have shown to significantly impacted bone formation, cartilage repair, and neurological tissue regeneration [1]–[4]. However, preparing piezoelectric and bioactive bone substitute materials remains a challenge in the field. Here, we report barium titanate composites in combination with established bone substitute materials, such as hydroxyapatite, or bioactive glass, as multi-functional bone substitute materials. By 3D printing, the piezoelectric composites are processed into porous and piezoelectric scaffolds, achieving piezoelectric constants d33 of 3-40 pC/N, which are in the range of native bone or above [5]. Especially with 45S5 bioactive glass, the materials show profound cytocompatibility and bioactive properties, inducing the formation of calcium phosphates on the scaffold surface. Piezoelectric composites based on barium titanate combined with modern manufacturing methods represent a promising approach to create bioactive and electrically stimulating implants. In the future, the electricity and bioactivity generated by such materials at the implant site may be harnessed without an external source or electrodes, thus acting as autonomous electroactive implants.

Author’s statement
Conflict of interest: Authors state no conflict of interest. Informed consent: Informed consent has been obtained from all individuals included in this study. Acknowledgments: This research was funded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB 1270/1,2 – 299150580.

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[2] B. Tandon, J. J. Blaker, and S. H. Cartmell, “Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair,” Acta Biomater., vol. 73, pp. 1–20, Jun. 2018.
[3] L. Leppik, K. M. C. Oliveira, M. B. Bhavsar, and J. H. Barker, “Electrical stimulation in bone tissue engineering treatments,” European Journal of Trauma and Emergency Surgery, vol. 46, no. 2. Springer, pp. 231–244, 01-Apr-2020.
[4] C. Polley et al., “3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering,” Materials (Basel)., vol. 13, no. 7, p. 1773, Apr. 2020.
[5] E. Fukada and I. Yasuda, “On the Piezoelectric Effect of Bone,” J. Phys. Soc. Japan, vol. 12, no. 10, pp. 1158–1162, Oct. 1957.

Article Details

How to Cite

Polley, C., Distler, T., Detsch, R., Boccaccini, A. R., & Seitz, H. (2023). Piezoelectric and bioactive composites: Functional materials for bone tissue engineering. Transactions on Additive Manufacturing Meets Medicine, 5(S1), 800.

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