Transactions on Additive Manufacturing Meets Medicine
Vol 3 No 1 (2021): Trans. AMMM
https://doi.org/10.18416/AMMM.2021.2109504

Scaffolds, Implants and Drug Delivery Systems, ID 504

Design and characterization of AM sensorized capsules for drug delivery devices

Main Article Content

Marta Graziano (Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy), David William Charig (Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy), Nicola Di Trani (Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA), Alessandro Grattoni (Department of Nanomedicine, Houston Methodist Research Institute, Houston and Department of Surgery, Houston Methodist Research Institute, Houston and Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030, USA), Giorgio De Pasquale (Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy)

Abstract

Long-acting drug delivery systems able to sustain the release of therapeutics in a controllable manner can provide several advantages in the treatment of chronic diseases. Given the high drug concentration in the reservoir, an inward osmotic fluid transport occurs across the membrane, which counters the outward diffusion of drugs. The resulting osmotic pressure buildup may be sufficient to cause the failure of implants with associated risks to patients. Confidently assessing the osmotic pressure buildup requires testing in vivo. Here, using metal and polymer additive manufacturing processes, we designed and developed implantable drug reservoirs with embedded strain sensors to directly measure the osmotic pressure in drug delivery implants in vitro and in vivo.

Article Details

How to Cite

Graziano, M., Charig, D. W., Di Trani, N., Grattoni, A., & De Pasquale, G. (2021). Design and characterization of AM sensorized capsules for drug delivery devices. Transactions on Additive Manufacturing Meets Medicine, 3(1), 504. https://doi.org/10.18416/AMMM.2021.2109504