Transactions on Additive Manufacturing Meets Medicine
Vol. 7 No. S1 (2025): Trans. AMMM Supplement
https://doi.org/10.18416/AMMM.2025.25062089

Printed Anatomy for Planning, Training, and Phantoms for Quality Assurance, ID 2089

Pressure profile measurements in cranial aneurysm models

Main Article Content

Roman Leonov (Fraunhofer IMTE \/ RWTH Aachen), Sonja Wichelmann (Fraunhofer Institute for Digital Medicine MEVIS, Lübeck, Germany), Hannes Schwenke (Centre for Neuroradiology, Medizinicum, Hamburg, Germany), Annika Dell (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany), André Behrends (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany), Thorsten Buzug (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany), Thomas Friedrich (Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering IMTE, Lübeck, Germany)

Abstract

Cranial aneurysms pose significant risks to patient health, possibly leading to subarachnoid haemorrhage, when the aneurysm wall becomes too thin as the aneurysm grows and subsequently cannot sustain the blood pressure inside the aneurysm sack, leading to rupture [1]. They are typically treated by implantation of different types of devices (coils or flow diverters) [2] to lower the pressure and the shear stress applied to the wall [3].


This study presents an experimental setup utilizing a cranial aneurysm model connected to a controlled pump system to simulate blood flow conditions typically observed in cranial arteries. The primary objective of this experiment is to investigate the pressure dynamics at the distal wall of an aneurysm, particularly focusing on the variations induced by the presence of an intravascular implant.


The aneurysm model, 3D printed with a Form 4 (Formlabs, Somerville, USA) using Clear resin, reflects the anatomical features of a cerebral aneurysm, since the 3D model was segmented using 3D Slicer software from the CT scan of a patient. The pump system is set to replicate physiological flow rates and pressures. A high-sensitivity pressure sensor PHE121 (EFE, Ivry-la-Bataille, France) is positioned to monitor the pressure applied to the aneurysm wall, providing critical data on how the wall's integrity is affected by both flow dynamics and the presence of an implant.


The results indicate how the introduction of an implant within the aneurysm changes the pressure profile, allowing for selection of treatment strategies. These findings contribute to a deeper understanding of the biomechanical environment of cranial aneurysms and the effectiveness of various intervention methods including novel ones.


In conclusion, this experimental model serves as a vital tool for investigating aneurysm behaviour under simulated physiological conditions, offering insights that could enhance clinical approaches to managing cranial aneurysms. Additionally, the sensor integration in vascular models can enhance the training experience if such models are used for education of interventionists. Further research is planned to explore new implant designs and their influence on pressure dynamics, with the aim of improving patient outcomes.

Article Details

How to Cite

Leonov, R., Wichelmann, S., Schwenke, H., Dell, A., Behrends, A., Buzug, T., & Friedrich, T. (2025). Pressure profile measurements in cranial aneurysm models. Transactions on Additive Manufacturing Meets Medicine, 7(S1), 2089. https://doi.org/10.18416/AMMM.2025.25062089

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