Current Issue

Vol 1 No 1 (2018): Proceedings on Cancer-Immuno-Oncology

DOI: https://doi.org/10.18416/CIO.2018.1810000

Immunogenicity / Biomarker

Human leukocyte antigens and haplotypes allow for prognostic classification of HNSCC patients
Gunnar Wichmann, Andreas Dietz, Susanne Wiegand
https://doi.org/10.18416/CIO.2018.1810001

Immunogenicity / Biomarker, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810001 • DOI: 10.18416/CIO.2018.1810001

Article-Views: 351  |  PDF-Downloads: 193
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Breaking the brake: targeting the immunosuppressive cells to optimize immunotherapy of cancer
Marco C. Merlano, Andrea Abbona, Ornella Garrone
https://doi.org/10.18416/CIO.2018.1810002

Immunogenicity / Biomarker, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810002 • DOI: 10.18416/CIO.2018.1810002

Article-Views: 291  |  PDF-Downloads: 170
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Immunotherapy and head and neck cancer: Focus on recurrent and metastatic disease
Robert Haddad
https://doi.org/10.18416/CIO.2018.1810004

Immunogenicity / Biomarker, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810004 • DOI: 10.18416/CIO.2018.1810004

Article-Views: 280  |  PDF-Downloads: 166
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Liquid Biopsy

Extracellular Vesicles as biomarkers for cancer progression and cancer associated VTE
Frank Gieseler, Fanny Ender
https://doi.org/10.18416/CIO.2018.1810005

Liquid Biopsy, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810005 • DOI: 10.18416/CIO.2018.1810005

Article-Views: 295  |  PDF-Downloads: 125
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Immune modulation by extracellular vesicles released from mesenchymal cells
Martina Seifert
https://doi.org/10.18416/CIO.2018.1810006

Liquid Biopsy, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810006 • DOI: 10.18416/CIO.2018.1810006

Article-Views: 344  |  PDF-Downloads: 169
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Cellular Vaccines

CAR NK cells for cancer retargeting
Ruth Esser, Ulrike Koehl, Wolfgang Glienke, Michael Morgan, Andrew Kaiser, Hinrich Abken, Michael Heuser, Krasimira Aleksandrova, Jana Leise, Olaf Oberschmidt, Christoph Priesner, Lubomir Arseniev, Axel Schambach, Stephan Kloess
https://doi.org/10.18416/CIO.2018.1810009

Cellular Vaccines, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810009 • DOI: 10.18416/CIO.2018.1810009

Article-Views: 520  |  PDF-Downloads: 240
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Immune biological rationale for the design of radioimmunotherapies
Udo S. Gaipl
https://doi.org/10.18416/CIO.2018.1810010

Cellular Vaccines, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810010 • DOI: 10.18416/CIO.2018.1810010

Article-Views: 264  |  PDF-Downloads: 161
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Role of resident memory T cells in cancer immunotherapy
Eric Tartour
https://doi.org/10.18416/CIO.2018.1810011

Cellular Vaccines, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810011 • DOI: 10.18416/CIO.2018.1810011

Article-Views: 300  |  PDF-Downloads: 168
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Perspectives of human gamma/delta T-cells in cancer immunotherapy
Dieter Kabelitz
https://doi.org/10.18416/CIO.2018.1810012

Cellular Vaccines, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810012 • DOI: 10.18416/CIO.2018.1810012

Article-Views: 312  |  PDF-Downloads: 135
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New Targets

On the development of personalized cancer vaccines
Hans-Georg Rammensee
https://doi.org/10.18416/CIO.2018.1810013

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810013 • DOI: 10.18416/CIO.2018.1810013

Article-Views: 273  |  PDF-Downloads: 157
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Platelets regulate innate immunity in autoinflammatory diseases and cancer
Bernardo Simoes Franklin
https://doi.org/10.18416/CIO.2018.1810014

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810014 • DOI: 10.18416/CIO.2018.1810014

Article-Views: 278  |  PDF-Downloads: 165
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A pan-cancer landscape of interactions between tumors and infiltrating immune cells
David Tamborero
https://doi.org/10.18416/CIO.2018.1810015

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810015 • DOI: 10.18416/CIO.2018.1810015

Article-Views: 321  |  PDF-Downloads: 177
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Rediscovering an old story: HLA class I alterations and immune escape of tumors in the context of immunotherapies
Barbara Seliger
https://doi.org/10.18416/CIO.2018.1810029

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810029 • DOI: 10.18416/CIO.2018.1810029

Article-Views: 286  |  PDF-Downloads: 163
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Biparatopic heavy chain antibodies (bi-hcAbs): fusion of two distinct CD38-specific nanobodies into a human IgG1 bi-hcAb results in potent CDC vs. myeloma cells
Kerstin Schütze, Julia Hambach, Katharina Petry, William Fumey, Birte Albrecht, Levin Schriewer, Jana Röckendorf, Stephan Menzel, Friedrich Haag, Catelijne Stortelers, Peter Bannas, Friedrich Koch-Nolte
https://doi.org/10.18416/CIO.2018.1810041

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810041 • DOI: 10.18416/CIO.2018.1810041

Article-Views: 343  |  PDF-Downloads: 187
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Activation of MDA5 improves anti-tumor therapy and reduces suppressive capacity of myeloid-derived suppressor cells
Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. König, Stefan Endres, Caroline C. Friedel, Max Schnurr, Peter Duewell
https://doi.org/10.18416/CIO.2018.1810042

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810042 • DOI: 10.18416/CIO.2018.1810042

Article-Views: 364  |  PDF-Downloads: 161
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Effect of both PD-1/PD-L1 and ERK inhibitor on Cisplatin-sensitive (HEY) and Cisplatin-resistant (HEY-Cis) ovarian cancer cell lines
Paulina Vogt, Frank Köster, Stephan Polack, Achim Rody, Karen Bräutigam
https://doi.org/10.18416/CIO.2018.1810043

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810043 • DOI: 10.18416/CIO.2018.1810043

Article-Views: 321  |  PDF-Downloads: 198
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Effect of both PD-1/PD-L1 and ERK inhibitor on triple negative breast cancer cell lines and the non-triple negative cell line MCF-7
Elodie Kabore, Frank Köster, Stephan Polack, Achim Rody, Karen Bräutigam
https://doi.org/10.18416/CIO.2018.1810044

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810044 • DOI: 10.18416/CIO.2018.1810044

Article-Views: 337  |  PDF-Downloads: 190
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Regulatory T cells in endogenous mouse lymphoma are antigen-specific nTregs and provide a target for immune checkpoint-inhibiting therapies
Vera Bauer, Fatima Ahmetlic, Tanja Riedel, Nico Trautwein, Tim Sparwasser, Stefan Stevanovic, Martin Röcken, Ralph Mocikat
https://doi.org/10.18416/CIO.2018.1810045

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810045 • DOI: 10.18416/CIO.2018.1810045

Article-Views: 342  |  PDF-Downloads: 196
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Specific targeting of oncogenic mutations using CRISPR-technology to destroy activated oncogenes and enhance immune response
Felix Oppel, Matthias Schürmann, Holger Sudhoff
https://doi.org/10.18416/CIO.2018.1810046

New Targets, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810046 • DOI: 10.18416/CIO.2018.1810046

Article-Views: 287  |  PDF-Downloads: 800
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Microbiome

Tumor and host factors regulating anti-tumor immunity and immotherapy efficacy
Thomas F. Gajewski
https://doi.org/10.18416/CIO.2018.1810019

Microbiome, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810019 • DOI: 10.18416/CIO.2018.1810019

Article-Views: 390  |  PDF-Downloads: 147
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Resistance / Immunosuppression

MDSC as a new target for cancer immunotherapy
Viktor Umansky
https://doi.org/10.18416/CIO.2018.1810022

Resistance / Immunosuppression, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810022 • DOI: 10.18416/CIO.2018.1810022

Article-Views: 260  |  PDF-Downloads: 168
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Neo-adjuvant checkpoint inhibition – the pathway towards personalized immunotherapy
Christian Blank
https://doi.org/10.18416/CIO.2018.1810023

Resistance / Immunosuppression, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810023 • DOI: 10.18416/CIO.2018.1810023

Article-Views: 315  |  PDF-Downloads: 173
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Interference between tumor mutational burden, HPV status, immune signatures and outcome in patients with head and neck cancer treated with chemoradiotherapy: Results from a multicenter retrospective study of the German Cancer Consortium Radiation Oncology
I. Tinhofer, T. Eder, A. K. Hess, V. Fleischer, P. Balermpas, C. Rödel, A. Linge, M. Krause, M. Baumann, M. Stuschke, D. Zips, A. L. Grosu, A. Abdollahi, J. Debus, U. Ganswindt, C. Belka, S. Pigorsch, G. Multhoff, S. E. Combs, V. Budach
https://doi.org/10.18416/CIO.2018.1810024

Resistance / Immunosuppression, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810024 • DOI: 10.18416/CIO.2018.1810024

Article-Views: 295  |  PDF-Downloads: 178
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Combinational Strategies

Dynamics of conversation: Immunotherapy meets tumor microenvironment
Iris Helfrich
https://doi.org/10.18416/CIO.2018.1810025

Combinational Strategies, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810025 • DOI: 10.18416/CIO.2018.1810025

Article-Views: 289  |  PDF-Downloads: 172
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Modulating the tumor microenvironment
Dirk Jäger
https://doi.org/10.18416/CIO.2018.1810027

Combinational Strategies, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810027 • DOI: 10.18416/CIO.2018.1810027

Article-Views: 226  |  PDF-Downloads: 142
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Immunomodulation / Tumor Biology

Integrin β4 synergizes with E-and P-selectin to regulate tumor growth: Unravelling the molecular mechanisms
Sandra Hanika, Vera Labitzky, Florian Gebauer, Daniel Wicklein, Hanna Maar, Tobias Gosau, Jennifer Schröder-Schwarz, Stefan Linder, Kristoffer Riecken, Udo Schumacher, Tobias Lange
https://doi.org/10.18416/CIO.2018.1810033

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810033 • DOI: 10.18416/CIO.2018.1810033

Article-Views: 324  |  PDF-Downloads: 168
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Primary and recurrent head and neck squamous carcinomas are strikingly different regarding their immune microenvironment
Christian Watermann, Helen Pasternack, Christian Idel, Sven Perner, Rosemarie Krupar, Julika Ribbat-Idel, Mark Philipp Kühnel, Danny Jonigk, Johannes Brägelmann
https://doi.org/10.18416/CIO.2018.1810035

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810035 • DOI: 10.18416/CIO.2018.1810035

Article-Views: 342  |  PDF-Downloads: 140
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The role of NFATc1 in T cell-mediated immune responses during the development of lung cancer
Lisanne Heim, Juliane Friedrich, Marina Engelhardt, Denis I. Trufa, Carol I. Geppert, Ralf J. Rieker, Horia Sirbu, Susetta Finotto
https://doi.org/10.18416/CIO.2018.1810036

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810036 • DOI: 10.18416/CIO.2018.1810036

Article-Views: 342  |  PDF-Downloads: 166
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Role of glycolysis for intestinal inflammation and carcinogenesis
Jacob Hamm, Kenneth Klischies, Nina Sommer, Philip Rosenstiel, Felix Sommer
https://doi.org/10.18416/CIO.2018.1810037

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810037 • DOI: 10.18416/CIO.2018.1810037

Article-Views: 286  |  PDF-Downloads: 170
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MALDI-imaging: Identification of protein signatures of genomic instability in colorectal cancers
Timo Gemoll, Oliver Klein, Elena Miroll, Christoph Thorns, Jens Habermann
https://doi.org/10.18416/CIO.2018.1810039

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810039 • DOI: 10.18416/CIO.2018.1810039

Article-Views: 290  |  PDF-Downloads: 171
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Investigating a potential role of Got1 in T cell exhaustion.
Nina Weisshaar
https://doi.org/10.18416/CIO.2018.1810040

Immunomodulation / Tumor Biology, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810040 • DOI: 10.18416/CIO.2018.1810040

Article-Views: 302  |  PDF-Downloads: 167
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Therapy Prognosis / Prediction

Effects of EGFR-MEK-ERK pathway on PD-L1 expression in head and neck squamous cell carcinoma
Chao Rong, Bohai Feng, Marie Muller, Dana Holzinger, Christa Flechtenmacher, Julia Thierauf, Annette Affolter, Peter Plinkert, Jochen Hess
https://doi.org/10.18416/CIO.2018.1810047

Therapy Prognosis / Prediction, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810047 • DOI: 10.18416/CIO.2018.1810047

Article-Views: 463  |  PDF-Downloads: 194
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The emerging role of extracellular vesicles in clinical research inflammation, cancer progression, metastasis
Fanny Ender, Melanie Klee, Mario Kramer, Axel Merseburger, Ralph Pries, Gabriela Riemekasten, Achim Rody, Barbara Wollenberg, Frank Gieseler
https://doi.org/10.18416/CIO.2018.1810048

Therapy Prognosis / Prediction, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810048 • DOI: 10.18416/CIO.2018.1810048

Article-Views: 298  |  PDF-Downloads: 169
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CD8+ T cell response to HPV16 E7 predicts survival outcome in oropharyngeal cancer
Holger Sudhoff, Liam Masterson, Piyush Jani, Jane Carolyn Sterling, Peter Goon
https://doi.org/10.18416/CIO.2018.1810050

Therapy Prognosis / Prediction, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810050 • DOI: 10.18416/CIO.2018.1810050

Article-Views: 267  |  PDF-Downloads: 154
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Therapeutic Strategies / Approaches

Current status of radiotherapy/radiochemotherapy and immunotherapy combinations– a German survey
Lukas Käsmann, Chukwuka Eze, Olarn Roengvoraphoj, Claus Belka, Farkhad Manapov
https://doi.org/10.18416/CIO.2018.1810051

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810051 • DOI: 10.18416/CIO.2018.1810051

Article-Views: 303  |  PDF-Downloads: 175
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Activation of immune response in refractory patients to standard treatment (T.R.A.N.S.L.A.T.E.)
Andrea Abbona, Dario Sangiolo, Marco Merlano, Ornella Garrone, Merlotti Anna, Martino Monteverde, Cristiana Lo Nigro, Antonella Falletta, Marcella Occelli, Chiara Varamo, Massimo Aglietta, Loretta Gammaitoni, Alessia Reali
https://doi.org/10.18416/CIO.2018.1810052

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810052 • DOI: 10.18416/CIO.2018.1810052

Article-Views: 290  |  PDF-Downloads: 146
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Which adjuvants for tumor-antigen vaccination induce powerful non-sialylated IgG antibodies?
Yannic Bartsch, Marc Ehlers
https://doi.org/10.18416/CIO.2018.1810053

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810053 • DOI: 10.18416/CIO.2018.1810053

Article-Views: 250  |  PDF-Downloads: 155
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Killing melanoma cells with ROS provides immuno-protection against tumor growth in vivo
Eric Freund, Ramona Clemen, Rajesh Kumar Gandhirajan, Sander Bekeschus
https://doi.org/10.18416/CIO.2018.1810055

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810055 • DOI: 10.18416/CIO.2018.1810055

Article-Views: 293  |  PDF-Downloads: 151
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Pre- and intratherapeutic cellular monitoring for dose adjustment of chemotherapy in aggressive lymphoma
Julia Schröder, Stefan Rödiger, Madeleine Ruhe, P. Markus Deckert
https://doi.org/10.18416/CIO.2018.1810056

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810056 • DOI: 10.18416/CIO.2018.1810056

Article-Views: 275  |  PDF-Downloads: 155
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Combining anti-VEGF-A and anti-PD-L1 therapy prolongs overall survival in small cell lung carcinomas
Lydia Meder, Philipp Schuldt, Martin Thelen, Anna Schmitt, Felix Dietlein, Sebastian Klein, Sven Borchmann, Kerstin Wennhold, Ignacija Vlasic, Sebastian Oberbeck, Richard Riedel, Alexandra Florin, Kristina Golfmann, Hans A. Schlößer, Margarete Odenthal, Reinhard Büttner, Jürgen Wolf, Michael Hallek, Marco Herling, Michael von Bergwelt-Baildon, H. Christian Reinhardt, Roland T. Ullrich
https://doi.org/10.18416/CIO.2018.1810057

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810057 • DOI: 10.18416/CIO.2018.1810057

Article-Views: 511  |  PDF-Downloads: 189
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Robust GMP manufacturing process with IL-2 and a glycoprotein antibody cocktail generates highly active human NK cell batches for cancer immunotherapy
Katharina Bröker, Udo Schumacher, Ralf Pörtner, Hans Hoffmeister, Evgeny Sinelnikov, Stefan Lüth, Werner Dammermann
https://doi.org/10.18416/CIO.2018.1810058

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810058 • DOI: 10.18416/CIO.2018.1810058

Article-Views: 295  |  PDF-Downloads: 159
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Progression of head and neck cancer is associated with elevated neutrophil extracellular traps formation by circulating neutrophils
Anna-Sophie Decker, Ekaterina Pylaeva, Alexandra Brenzel, Sharareh Bordbari, Ilona Spyra, Stephan Lang, Jadwiga Jablonska
https://doi.org/10.18416/CIO.2018.1810059

Therapeutic Strategies / Approaches, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810059 • DOI: 10.18416/CIO.2018.1810059

Article-Views: 344  |  PDF-Downloads: 189
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