Proceedings on Cancer-Immuno-Oncology
Vol. 1 No. 1 (2018): Proceedings on Cancer-Immuno-Oncology
https://doi.org/10.18416/CIO.2018.1810027

Combinational Strategies, ID Proceedings on Cancer-Immuno-Oncology, Vol 1, No 1, 2018 • Article ID: 1810027 • DOI: 10.18416/CIO.2018.1810027

Modulating the tumor microenvironment

Main Article Content

Dirk Jäger 

Copyright (c) 2018 Dirk Jäger

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Immunotherapy works in some patients, in most patients it does not. We have tumor entities that show low objective response rates like CRC or PDAC. We identified the immunosuppressive environment being the main mechanisms of resistance. Therefore strategies that target such suppressive mechanisms are being developed clinically. We currently evaluate CCR5 blockade in combination with checkpoint inhibition in MSS-CRC and PDAC.

Article Details