Proceedings on Automation in Medical Engineering
Vol. 1 No. 1 (2020): Proc AUTOMED

Automation in lung support and ventilation, ID 010

A mathematical model for the respiratory central pattern generator

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Annika Multusch (Institut für Medizinische Elektrotechnik, Universität zu Lübeck), Eike Petersen (Institut für Medizinische Elektrotechnik, Universität zu Lübeck)


The respiratory Central Pattern Generator (rCPG) is a neural circuit located in the brainstem, generating the physiological rhythmic breathing pattern of alternating inspiration and expiration. In this work, we propose a mathematical model of the rCPG which incorporates physiological feedback mechanisms. Numerical simulations of a closed-loop model of the rCPG with a lung and gas exchange model confirm the ability of the proposed model to reproduce the behavior of the rCPG in several important physiological regimes.

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